The VALIDATE Network - Vaccine development for complex intracellular neglected pathogens
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Funded Pump-priming Projects

VALIDATE funds pump-priming grants for research projects aiming to accelerate vaccine development for our focus pathogens. You can find out about applying on the Pump Priming Grants page. Below are the current and past pump-priming projects funded by VALIDATE.

 

 

Grant call round #6 - March 2025

Luciana Balboa

Accelerating BCG Efficacy: Targeting Dendritic Cell Migration in Tuberculosis Immunization

Suraj Bhattarai

Burden of Burkholderia pseudomallei in Nepal to inform vaccine needs (BURNEP study)

Julen Tomás Cortázar

Development of Versatile and Cost-Effective Next-Generation Vaccines through Multivalent Approaches

VALIDATE Member Photo

Determining the metabolic impact of BCG vaccination

Alba Llibre Serradell

Profiling the mycobacterial immune response in human lung tissue to inform novel TB vaccine design

Menberework Negatue

Immune Signatures of Chronic Tuberculosis and Cutaneous Leishmaniasis

Mark Shiburah

Assessing the immunogenicity and protective efficacy of a telomerase deficient Leishmania major

VALIDATE Member Photo

CCR4LEP: Exploring CCR4 as immune correlate of protection for leprosy

Gabriel Wagner-Lichtenegger

Melio MuSe: Multiplex Serology advancing multicomponent melioidosis vaccines

Andy Tran

Comparative testing of Ag85 isoforms and consensus sequence optimisation for next-gen TB vaccines

Grant call round #5 - March 2022

Ana Valencia-Hernandez

Evaluation of BCGΔBCG1419c::ESAT6-PE25SS in immunocompetent and immunocompromised mouse models of TB

Laura Sibley

Characterising the cytokines associated with trained innate immunity in BCG vaccinated non-human primates

Munyaradzi Musvosvi

Towards a T cell subset that can control Mycobacterium tuberculosis infection

Paula Niewold

Towards a better TB vaccine: understanding improved local immune control by mucosal BCG vaccination

diane lee

Alvacc: A human in vitro alveolus model to study aerogenic TB vaccine binding and translocation

Andy Tran

Testing a novel, self-adjuvanting mucosal vaccine candidate for TB in the mouse model of infection

Grant call round #4 - November 2019

Justice Boakye-Appiah

Cross protection against TB by attenuated Mycobacterium ulcerans strain 5114

Chiranjay Mukhopadhyay

Characterising the cellular immunity and metabolic response to Mycobacterium tuberculosis and Burkholderia pseudomallei in Indian patients for vaccine design

Gabriele Pollara

T cell receptor sequencing to identify correlates of protection in human tuberculosis vaccine studies

Matthew Rogers

Modelling the impact of a transmission blocking vaccine against leishmaniasis on sand fly vectorial capacity

Samantha Sampson

An ex vivo model for understanding the impact of vaccination on Mycobacterial persister populations

Iman Satti

Investigating the BCG-induced Natural Killer (NK) cell response in cattle and humans

Lisa Stockdale

Cytomegalovirus as a risk factor for TB and leishmaniasis

Simon Waddell

Innovative tools to measure mycobacterial antigen expression in tissue

Grant call round #3 - March 2019

Myron Christodoulides

Protective efficacy of conserved Leishmania hypothetical proteins against visceral leishmaniasis

Rhea Coler

Development of an RNA based vaccine against Mycobacterium tuberculosis

Francisco Javier Sánchez-Garcia

Metabolic reprogramming of skin microenvironment for improved BCG vaccine efficacy

Elena Stylianou

Developing a mouse model of diabetes to evaluate vaccines for TB and melioidosis

Julen Tomás Cortázar

Elucidating the T-cell epitopes and T-cells responses of two B. pseudomallei vaccine antigens

Monitoring and Addressing Challenging Risks, Rumours and Reputations Across the GCRF Vaccinology Networks

In 2018 three of the GCRF Vaccinology Networks, VALIDATE, HIC-VAC and IMPRINT, joined together to co-fund an 18-month long project based at the Vaccine Confidence ProjectTM at LSHTM. Read more below.

Heidi Larson

Vaccine Confidence Project

Grant call round #2 - June 2018

VALIDATE Member Photo

In vivo protection studies of chimeric Burkholderia pseudomallei antigens presenting multiple epitopes on protein scaffolds and outer membrane vesicles

Susanna Dunachie

Vaccines to target people with diabetes: characterising the pathways of immune response to M. tuberculosis and B. pseudomallei in people with diabetes compared to non-diabetics

Mohamed Osman

Identification of Leishmania donovani and Mycobacterium tuberculosis- derived proteins on the surface of infected macrophages that are associated with ADCC induction

Grant call round #1 - November 2017

Lucia Biffar

Natural variation of the bovine lymph node microenvironment and its possible effect on BCG immunogenicity

Delia Boccia

Enhancing BCG efficacy: the Social Technology Lab Initiative

Panjaporn Chaichana

Establishment of a functional assay panel to evaluate the role of antibodies in defence against melioidosis and tuberculosis

Rajko Reljic

Overcoming innate immune tolerance in the respiratory tract for optimal vaccine design

Javier Salguero Bodes

The effect of BCG vaccination in immune responses against visceral leishmaniasis in a natural (canine) model of infection

Steven Smith

How do functional and metabolic characteristics of trained monocytes affect their anti-bacterial activity?